Study on the digestion-induced changes in the characteristics and bioactivity of Korean native and overseas cattle-derived peptides

Jae Hyeon Kim1, Da Young Lee1, Seung Yun Lee2, Ermie Jr. Mariano1, Jae Won Jeong1, Seung Hyeon Yun1, Juhyun Lee1, Jinmo Park1, Yeongwoo Choi1, Dahee Han1, Jin Soo Kim1, Cheorun Jo3, Sun Jin Hur1,*
Author Information & Copyright
1Department of Animal Science and Technology, Chung-Ang University, Anseong 17546, Korea.
2Division of Animal Science, Division of Applied Life Science (BK21 Four), Institute of Agriculture & Life Science, Gyeongsang National University, Jinju 52828, Korea.
3Department of Agricultural Biotechnology, Center for Food and Bioconvergence, and Research Institute of Agriculture and Life Science, Seoul National University, Seoul 08826, Korea.
*Corresponding Author: Sun Jin Hur. E-mail:

© Copyright 2023 Korean Society for Food Science of Animal Resources. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: Jul 14, 2023 ; Revised: Sep 01, 2023 ; Accepted: Sep 27, 2023

Published Online: Oct 05, 2023


This study was conducted to compare and analyze the changes in the biochemical characteristics and biological activity of peptide extracts derived from Chickso, Hanwoo, and Wagyu beef during digestion. The results of the in vitro digestion analysis revealed that the digestion rate, total free amino acid content, and antioxidant and antihypertensive activities of Chickso loin and shank myofibrillar proteins were significantly higher (p < 0.05) than those of Hanwoo and Wagyu loin and shank myofibrillar proteins. Particularly, the peptide extracts of Chickso loin and shank had a high angiotensin-converting enzyme inhibitory activity. In mice in vivo digestion experiment, the blood serum of mice fed with Chickso loin peptide extract (< 10 kDa) showed the highest antioxidant enzyme activity. Thus, Chickso peptide extracts was deemed to be similar or more bioactive than Hanwoo and Wagyu peptide extracts, and can be used as bioactive materials.

Keywords: Korean native cattle; Chickso; Peptide extracts; Antioxidant activity; Antihypertensive activity