Animal Models of Cognitive Deficits for Probiotic Treatment

Oh Yun Kwon1, Seung Ho Lee1,*
Author Information & Copyright
1Department of Nano-Bioengineering, Incheon National University, Incheon 22122, Korea.
*Corresponding Author: Seung Ho Lee, Department of Nano-Bioengineering, Incheon National University, Incheon 22122, Korea. E-mail:

© Copyright 2022 Korean Society for Food Science of Animal Resources. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: Jul 21, 2022 ; Revised: Aug 04, 2022 ; Accepted: Aug 11, 2022

Published Online: Aug 12, 2022


Cognitive dysfunction is a common symptom of neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease, and is known to be caused by the structural and functional loss of neurons. Many natural agents that can improve cognitive function have been developed and assessed for efficacy using various cognitive deficit animal models. As the gut environment is known to be closely connected to brain function, probiotics are attracting attention as an effective treatment target that can prevent and mitigate cognitive deficits as a result of neurodegenerative diseases. Thus, the objective of this review is to provide useful information about the types and characteristics of cognitive deficit animal models, which can be used to evaluate the anti-cognitive effects of probiotics. In addition, this work reviewed recent studies describing the effects and treatment conditions of probiotics on cognitive deficit animal models. Collectively, this review shows the potential of probiotics as edible natural agents that can mitigate cognitive impairment. It also provides useful information for the design of probiotic treatments for cognitive deficit patients in future clinical studies.

Keywords: Cognitive deficits; Probiotics; Neurodegenerative disease; Gut–Brain Axis