Antihypertensive Effect of Milk Fermented by Lactiplantibacillus plantarum K79 on Spontaneously Hypertensive Rats

Sang-Dong Lim1,*, Kyungwon Lee1, Taewon Han1, Hyunjhung Jhun1, Ah-Ram Han1, Yongjin Hwang2, Sangpil Hong1
Author Information & Copyright
1Korea Food Research Institute, Wanju 55365, Korea
2Novalacto co., Ltd, Daejeon 34016, Korea
*Corresponding Author: Sang-Dong Lim. E-mail:

© Copyright 2023 Korean Society for Food Science of Animal Resources. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: Sep 06, 2023 ; Revised: Oct 16, 2023 ; Accepted: Oct 17, 2023

Published Online: Nov 14, 2023


The aim of this study is to investigate whether milk fermented by Lactiplantibacillus plantarum K79, which exhibits ACE inhibitory activity, has an effect on lowering the blood pressure of hypertensive rats and to investigate biomarker changes in their blood. Experimental group: normal group (NG, WKY): distilled water, control group (NCG, SHR): distilled water, high treatment group (HTG, SHR): 500 mg/kg/day, medium treatment group (MTG, SHR): 335 mg/kg/day, low treatment group (LTG, SHR): 170 mg/kg/day, positive control group(PCG, SHR): Enalapril, 10 mg/kg/day. The experimental animals used in this study were divided into groups composed of 8 animals. In terms of weight change, a significant difference was observed between the normal group and the SHR group, but there was no significant difference between the SHR group. After 8 weeks of feeding, Blood pressure was lowered more significantly in the HTG(209.9±13.3 mmHg) than in the NCG(230.8±7.3 mmHg). The treatment group has an effect of lowering blood pressure by significantly suppressing blood pressure-related biomarker protein expression than NG. The results obtained can be used as an antihypertensive material in a variety of food raw materials.

Keywords: fermented milk; hypertension; Lactiplantibacillus plantarum; spontaneously hypertensive rats; angiotensin converting enzyme