Table 2. KEGG pathway analysis of differentially expressed genes between negative control and bovine colostrum-derived extracellular vesicles treated Akkermansia muciniphila

Upregulated			Downregulated
Gene	Description	FC	Gene	Description	FC
Two-component system			Protein export
Amuc_0736	Protein tyrosine phosphatase	1.678	Amuc_0240	Twin-arginine translocation protein, TatA/E family subunit	–1.567
Amuc_0830	Potassium-transporting ATPase, A subunit	1.569	Amuc_1047	Preprotein translocase, SecE subunit	–1.670
Amuc_1153	Potassium-transporting ATPase, C subunit	1.897
Nitrogen metabolism
Amuc_1252	Glutamine synthetase catalytic region	2.057
Amuc_1253	Glutamate synthase (ferredoxin)	2.249

KEGG, Kyoto Encyclopedia of Genes and Genomes; FC, fold change.