Table 2. A summary of glycomacropeptide (GMP) effects on gut microbiome diversity

Area/criteria of study Specific effect Reference
General population health Decrease Streptococcus abundance in the gut Hansen et al., 2023
Enhance indicators of satiety and glycemic control
Positive relationship of GMP+galacto-oligosaccharide (GOS) feeding with increased mRNA transcript levels for claudin-1, claudin-2, occludin, mucin-4, and mucin-13 Wu et al., 2020
Changes in the microbiome were positively correlated with antidiabetic effects after feeding GMP hydrolysates Yuan et al., 2020
Maternal GMP+GOS supplementation improved litter characteristics in piglet (number of live and healthy piglets, total litter weight, and average birth weight of live piglets) Wu et al., 2020
Maternal GMP+GOS supplementation increased immunoglobulins (IgA, IGF-1, IgG, IgM) in neonatal piglets
Microbiome – Dysbiosis Increased Lactobacillus, stable Bifidobacterium, decreased Bacteroides, Clostridium, and Escherichia coli in human fecal cultures Brück et al., 2003
Improved microbial diversity in an artificial colon model for elderly people: Increased growth of Coprococcus, Clostridium cluster XIVb, Roseburia; decreased Dorea Ntemiri et al., 2017
Reduced Helicobacteraceae; increased Ruminococcaceae, Bacteroidales_S24-7_group in mice with type-2 diabetes Yuan et al., 2020