| Senescence-accelerated mouse prone (SAMP) | SAMP8 mice | - | - | Age-associated increase in Aβ deposition in hippocampal from 4 to 12 mon ⟹ Astrogliosis, microgliosis, and cognitive deficits | (Takeda et al., 1981) |
| Single APP knock-in | AppNL-G-F mice | Endogenous APP | APPKM670/671NL, E693G, I716F | Aβ plaque deposition observed starting at 2 mon and is nearly saturated by 7 mon ⟹ Gliosis and cognitive deficits | (Guerreiro et al., 2010; Mullan et al., 1992; Nilsberth et al., 2001) |
| Double transgenic APP-Tg × PSEN1-Tg | APP/PS1 transgenic mice | Mouse Thy1 (APP, PS1) | APPKM670/671NL PS1I166P | Aβ plaque deposition starting at approximately 6 wk of age in the neocortex ⟹ Astrogliosis, microgliosis, formation of dystrophic neuritis, neuronal loss, and cognitive deficits | (Maia et al., 2013; Radde et al., 2006) |
| 5xFAD transgenic mice | Mouse Thy1.2 (APP, PS1) | APPKM670/671NL, I716V, V717I PS1M146L, L286V | Neuron loss occurs in multiple brain regions beginning at 6 mon of age ⟹ Astrogliosis, microgliosis, neuronal loss, and cognitive deficits | (Devi and Ohno, 2010; Oakley et al., 2006) |
| Triple transgenic | 3xTg-AD mice | Mouse Thy1.2 (APP) Endogenous (PS1) | APPK670N, M671L PS1M146V MAPTP301L | Aβ deposition with intracellular immunoreactivity detected in some brain regions as early as 3–4 mon of age ⟹ Gliosis and cognitive deficits | (Oddo et al., 2003) |